Macrophage migration inhibitory factor (MIF) gene polymorphisms are associated with increased prostate cancer incidence
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چکیده
منابع مشابه
Macrophage migration inhibitory factor (MIF) enzymatic activity and lung cancer.
The cytokine macrophage migration inhibitory factor (MIF) possesses unique tautomerase enzymatic activity, which contributes to the biological functional activity of MIF. In this study, we investigated the effects of blocking the hydrophobic active site of the tautomerase activity of MIF in the pathogenesis of lung cancer. To address this, we initially established a Lewis lung carcinoma (LLC) m...
متن کاملHuman Anti-macrophage Migration Inhibitory Factor (mif) Antibodies Inhibit Growth of Human Prostate Cancer Cells
Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine, originally discovered for its eponymous effect and now known for pleiotropic biological properties in immunology and oncology. Circulating MIF levels are elevated in several types of human cancer including prostate cancer. MIF is released presumably by both, stromal and tumor cells and enhances malignant growth and meta...
متن کاملCorrelation between urine macrophage migration inhibitory factor (MIF)/creatinine ratio and time after kidney transplantation
Abstract Background: Despite the long-standing association of macrophage migration inhibitory factor (MIF) with delayed-type hypersensitivity response, the potential role of MIF in chronic allograft nephropathy is unknown. The association between upregulation of MIF expression, macrophage and T cell infiltration and the severity of chronic allograft nephropathy suggests that MIF may be an ...
متن کاملIncreased serum levels of macrophage migration inhibitory factor (MIF) in patients with microscopic polyangiitis
OBJECTIVE To test the hypothesis that macrophage migration inhibitory factor (MIF) is involved in the disease activity of systemic vasculitis. METHODS Patients with systemic vasculitis were divided into three groups based on the size of the affected vessels. Microscopic polyangiitis (MPA) was considered as small vessel vasculitis (SVV), polyarteritis nodosa as medium-sized vessel vasculitis (...
متن کاملMacrophage migration inhibitory factor (MIF), a role in COPD
Authors: 5 Gunnar R. Husebø, Per S. Bakke, Rune Grønseth, Jon A. Hardie, Thor Ueland, Pål 6 Aukrust, Tomas M.L. Eagan. 7 8 Dept. of Thoracic Medicine, Haukeland University Hospital, Bergen Norway 9 2 Dept. of Clinical Science, University of Bergen, Norway 10 Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway 11 K.G. Jebsen Inflammatory Research Centre...
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ژورنال
عنوان ژورنال: Genes & Immunity
سال: 2007
ISSN: 1466-4879,1476-5470
DOI: 10.1038/sj.gene.6364427